Prediabetes Progression and Regression on Objectively- Measured Physical Function: A Prospective Cohort Study

BackgroundPrediabetes leads to declines in physical function older adults, but the impact of prediabetes progression or regression on is unknown. This study assessed this longitudinal association, with objectivelymeasured by grip strength, walking speed, and standing balance, based Health Retirement Study enrolling United States adults aged >50 years. MethodsParticipants were followed-up for 4-year ascertain status alteration (maintained, regressed, progressed), another assess their impacts function. Weak strength was defined as <26 kg men <16 women, slow speed <0.8 m/sec, poor balance an uncompleted fulltandem testing. Logistic linear analyses performed. ResultsOf included 1,511 participants prediabetes, 700 maintained 306 progressed diabetes, 505 regressed normoglycemia over 4 Grip declined from baseline during followup, regardless alteration. Compared maintenance, increased odds developing weak 89% (95% confidence interval [CI], 0.04 2.44) exhibited larger 0.85 CI, –1.65 –0.04). However, not related impairments balance. Prediabetes also did affect any measures ConclusionPrediabetes accelerates decline aging population, while may prevent due aging.